XR5944: A potent inhibitor of estrogen receptors
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چکیده
منابع مشابه
XR5944: A potent inhibitor of estrogen receptors.
The anticancer drug XR5944 was originally developed as a topoisomerase inhibitor and was subsequently shown to be a transcription inhibitor. It has shown exceptional anticancer activity both in vitro and in vivo and was significantly more potent than traditional topoisomerase inhibitors. The solution structure of the XR5944/DNA complex recently obtained in our laboratory indicates that XR5944 b...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2007
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-06-0392